Biotin and derivatives
Medchemexpress LLC 3aS 4S 6aR -Biotin- 100mg
(3aS 4S 6aR)-Biotin-PEG4-Alkyne is an alkyne-activated biotinylation reagent (3aS 4S 6aR)-Biotin-PEG4-Alkyne can be reacted with azides via a copper-catalyzed click reaction Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection[1]
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1237.34 | C54H96N2O29
Bis-PEG21-NHS ester is a polyethylene glycol (PEG)-based bifunctional N-hydroxysuccinimide (NHS) ester linker used for bioconjugation. It provides a hydrophilic PEG21 spacer with two NHS-activated ester termini for conjugation to primary amines and is used in the synthesis of antibody-drug conjugates and PROTAC linkers. Typical purity is 98.0% and molecular weight is 1,237.34.
- Bifunctional PEG linker with two NHS ester termini.
- Hydrophilic PEG21 spacer to improve solubility.
- Suitable for ADC and PROTAC linker synthesis.
- High purity (98.0%) for research applications.
- Available in multiple pack sizes for synthetic workflows.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis(9CI) | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 5 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203833.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis[oxy(1-oxo-3,1-propanediyl)oxy]]bis(9CI) | 65869-63-8 | 99.2% | 400.34 | C16H20N2O10 | 5 G
Bis-PEG2-NHS ester is a non-cleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC). It contains an N-hydroxysuccinimide (NHS) ester reactive group for efficient amine coupling and is supplied as a white to off-white solid.
- Non-cleavable two-unit PEG linker
- NHS-ester functional group for amine coupling
- High purity suitable for conjugation chemistry
- Available in multiple pack sizes, including 5 G
- Powder storage: -20°C for up to 3 years
Medchemexpress LLC M-PEG-NHS ester | 92451-01-9 | 98.0% | (C2H4O)nC7H9NO5 | 50 MG
M-PEG-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Protacs contain two different ligands connected by a linker
- Features a ligand for an E3 ubiquitin ligase and another for the target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Biotin-PEG3-benzophenone | 756525-96-9 | MFCD13184950 | 98.7% | 654.82 g/mol | C34H46N4O7S | 10 MG
Biotin-PEG3-benzophenone is a biotin-labeled benzophenone derivative used as a photosensitizer and affinity probe for photolabeling and enrichment of biomolecules. The compound couples a benzophenone photo-crosslinker to a biotin affinity tag via a PEG3 spacer, enabling efficient photolabeling workflows in biochemical and proteomic studies.
- Enables efficient photo-crosslinking and covalent capture of interacting partners.
- Biotin tag allows streptavidin-based enrichment and detection.
- PEG3 spacer improves solubility and reduces steric hindrance.
- High purity suitable for biochemical assays.
Medchemexpress LLC DBCO-NHS ester | 1353016-71-3 | 99.5% | 402.40 g/mol | C23H18N2O5 | 100 MG
DBCO-NHS ester is an N-hydroxysuccinimide (NHS) activated ester bearing a dibenzocyclooctyne (DBCO) moiety, used as a non-cleavable linker and click-chemistry reagent for bioconjugation and antibody-drug conjugate construction.
- Non-cleavable ADC linker suitable for bioconjugation.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-functionalized partners.
- High purity (reported ~99.5%).
- Physical form: solid; color white to yellow.
- Storage: powder -20°C (3 years); in solvent -80°C (6 months) or -20°C (1 month).
- Molecular formula C23H18N2O5; molecular weight 402.40 g/mol.
Medchemexpress LLC Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 250 MG
Aeide-C1-NHS ester | 824426-32-6 | 98.0% | C6H6N4O4 | 250 MG
Medchemexpress LLC Biotin-LC-LC-NHS | 89889-52-1 | 98.0% | 567.7 g/mol | C26H41N5O7S | 50 MG
Biotin-LC-LC-NHS is a long-chain N-hydroxysuccinimide (NHS) activated biotinylation reagent used to label proteins, antibodies, and small molecules. The LC-LC spacer reduces steric hindrance during conjugation, and the NHS ester reacts with primary amines to form stable amide bonds.
- Provides long-chain spacer (LC-LC) to reduce steric hindrance.
- Reactive NHS ester for amine-selective conjugation.
- Suitable for labeling antibodies and small molecules.
- Solid, white to light yellow appearance; store under inert gas and protect from light.
- Soluble in DMSO; follow recommended solvent and storage guidance.
Medchemexpress LLC Biotin-PEG10-NHS ester | 98.0% | C37H64N4O16S | 25 MG
This PEG-based linker is utilized in the synthesis of degraders, specifically within the PROTAC (Proteolysis Targeting Chimeras) modality. PROTACs are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. They function by connecting a ligand for an E3 ubiquitin ligase with a ligand for the target protein.
- Intended for research use only
Medchemexpress LLC NSP-SA-NHS | 199293-83-9 | 99.65% | 50 MG
NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed.
- Application: Chemiluminescent immunoassay.
- Specific use: Developed for a rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA).
Medchemexpress LLC Bis-SS-C3-NHS ester | 98604-88-7 | 98.0% | 432.47 g/mol | C16H20N2O8S2 | 10 MG
Bis-SS-C3-NHS ester is a cleavable disulfide-containing N-hydroxysuccinimide (NHS) ester linker used for bioconjugation. It reacts with primary amines to form stable amide bonds, and the internal disulfide provides a reducible linkage for intracellular payload release, making it suitable for antibody-drug conjugate synthesis and conjugation method development.
- Cleavable disulfide linker for controlled payload release
- N-hydroxysuccinimide (NHS) ester reactive toward primary amines
- High purity suitable for research-scale conjugation
- Available in multiple small-scale pack sizes for method development
- Stable when stored sealed at -20°C and protected from moisture
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 g/mol | C14H24N6O3S | 10 MG
Biotin-PEG1-azide is a biotinylated polyethylene glycol (PEG1) azide reagent used as a cleavable linker and click chemistry handle for bioconjugation and antibody-drug conjugate synthesis. It provides an azide functional group for copper-catalyzed or strain-promoted azide-alkyne cycloaddition, enabling attachment to alkyne-containing partners.
- Biotinylated PEG1 structure with terminal azide functional group.
- Suitable for CuAAC and SPAAC click chemistry reactions.
- High purity for research applications.
- Oil appearance; store frozen for stability.
- Available in small milligram pack sizes for laboratory use.
![Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis(oxy(1-oxo-3,1-propanediyl)oxy)]bis- (9CI) | 65869-63-8 | >=98.0% | 400.34 g/mol | C16H20N2O10 | 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203149.png-250.jpg)
Medchemexpress LLC 2,5-pyrrolidinedione, 1,1'-[1,2-ethanediylbis(oxy(1-oxo-3,1-propanediyl)oxy)]bis- (9CI) | 65869-63-8 | >=98.0% | 400.34 g/mol | C16H20N2O10 | 1 G
Bis-PEG2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester functional groups for antibody-agent conjugation and general amine coupling. It increases solubility and provides a short hydrophilic spacer between biomolecules and payloads.
- Noncleavable PEG2 linker with two NHS ester reactive groups.
- Enhances hydrophilicity and solubility of conjugates.
- Suitable for antibody-drug conjugation and amine labeling.
- White to off-white solid; stable as powder at -20°C for long-term storage.
- Typical purity ≥98.0% by NMR.